Moiseenko V M, Semiglazov V F, Klimashevskiĭ V F, Semiachkina S O, Chernomordikova M F, Pozharisskiĭ K M
Vopr Onkol. 1991;37(2):174-9.
Potential and actual rates of tumor growth were assayed in 13 patients with primary breast cancer. Potential growth rate was calculated according to proliferative activity as assessed by histoautoradiography whereas actual growth--on the basis of changes in tumor size observed on mammograms obtained through the course of the disease. Actual tumor doubling time proved 22.8 times longer (which means that tumors grew slower) than that suggested by proliferative activity. Cell loss at the average rate of 95.5% proved the main reason accounting for the difference. The proliferative activity in regional lymph node metastases measured in 3 patients simultaneously with the primary tumor assay was 3.9 times higher.
对13例原发性乳腺癌患者的肿瘤潜在生长率和实际生长率进行了测定。潜在生长率根据组织自显影评估的增殖活性计算，而实际生长率则基于在疾病过程中获得的乳房X线照片上观察到的肿瘤大小变化。实际肿瘤倍增时间比增殖活性所提示的时间长22.8倍（这意味着肿瘤生长较慢）。平均95.5%的细胞丢失率是造成这种差异的主要原因。在3例患者中，与原发性肿瘤检测同时进行的区域淋巴结转移的增殖活性高3.9倍。
