Neslihan Dikmenoğlu, Nurten Seringeç
Department of Physiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Arch Environ Occup Health. 2010 Jan-Mar;65(1):49-53. doi: 10.1080/19338240903392640.
Both blood viscosity and carbon monoxide (CO) has been associated with cardiovascular diseases (CVDs). In order to investigate the effects of chronic low-level CO exposure on the determinants of blood viscosity (hematocrit, plasma viscosity, erythrocyte deformability, and erythrocyte aggregation), 10 men exposed to CO at work for at least 6 months and 10 healthy controls were included in the study. Plasma viscosity was determined by a cone-plate viscometer, erythrocyte deformability and erythrocyte aggregation by laser-assisted optical rotational cell analyzer. Mean plasma viscosity of the group exposed to CO (1.4 +/- 0.1 mPa.sn) was significantly higher than that of the controls (1.2 +/- 0.06 mPa.sn) (p < .05). Plasma fibrinogen level of the CO group (275 +/- 11 mg/dL) was slightly higher than that of the controls (263 +/- 14 mg/dL). The rise in plasma viscosity by chronic low-level CO exposure may be the mechanism of CO-induced increase in the risk for CVDs.
血液黏度和一氧化碳（CO）均与心血管疾病（CVD）有关。为了研究长期低水平接触CO对血液黏度决定因素（血细胞比容、血浆黏度、红细胞变形性和红细胞聚集性）的影响，本研究纳入了10名职业性接触CO至少6个月的男性和10名健康对照者。血浆黏度通过锥板式黏度计测定，红细胞变形性和红细胞聚集性通过激光辅助光学旋转细胞分析仪测定。接触CO组的平均血浆黏度（1.4±0.1mPa·s）显著高于对照组（1.2±0.06mPa·s）（p<0.05）。CO组的血浆纤维蛋白原水平（275±11mg/dL）略高于对照组（263±14mg/dL）。长期低水平接触CO导致的血浆黏度升高可能是CO致CVD风险增加的机制。
