下丘脑室旁核在发热和心力衰竭期间调节肾交感神经活动和血流中的作用。
Role of the hypothalamic PVN in the regulation of renal sympathetic nerve activity and blood flow during hyperthermia and in heart failure.
机构信息
School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora 3083, Melbourne, Victoria, Australia.
出版信息
Am J Physiol Renal Physiol. 2010 Apr;298(4):F839-46. doi: 10.1152/ajprenal.00734.2009. Epub 2010 Feb 10.
Abstract
The hypothalamic paraventricular nucleus is a key integrative area in the brain involved in influencing sympathetic nerve activity and in the release of hormones or releasing factors that contribute to regulating body fluid homeostasis and endocrine function. The endocrine and hormonal regulatory function of the paraventricular nucleus is well studied, but the regulation of sympathetic nerve activity and blood flow by this region is less clear. Here we review the critical role of the paraventricular nucleus in regulating renal blood blow during hyperthermia and the evidence pointing to an important pathophysiological role of the paraventricular nucleus in the elevated renal sympathetic nerve activity that is a characteristic of heart failure.
摘要
下丘脑室旁核是大脑中一个关键的整合区域，参与影响交感神经活动以及激素或释放因子的释放，这些激素或释放因子有助于调节体液平衡和内分泌功能。室旁核的内分泌和激素调节功能得到了很好的研究，但该区域对交感神经活动和血液流动的调节作用还不太清楚。在这里，我们回顾了室旁核在调节发热时肾脏血液灌注中的关键作用，并提供了证据表明室旁核在心力衰竭时升高的肾交感神经活动中起着重要的病理生理作用。
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