Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA.
J Biol Chem. 2010 Apr 9;285(15):11033-8. doi: 10.1074/jbc.R109.075044. Epub 2010 Feb 10.
Given the role of transcriptional misregulation in the pathogenesis of human disease, there is enormous interest in the development of molecules that exogenously control transcription in a defined manner. The past decade has seen many exciting advancements in the identification of molecules that mimic or inhibit the interactions between natural transcriptional activators and their binding partners. In this minireview, we focus on four activator.target protein complexes, highlighting recent advances as well as challenges in the field.
鉴于转录失调在人类疾病发病机制中的作用，人们对外源性以特定方式控制转录的分子的开发产生了巨大的兴趣。在过去的十年中，人们在鉴定模拟或抑制天然转录激活因子与其结合伙伴之间相互作用的分子方面取得了许多令人兴奋的进展。在这篇小综述中，我们重点介绍了四个激活剂-靶蛋白复合物，突出了该领域的最新进展和挑战。
