增强的全基因组核苷酸切除修复可减少紫外线致癌作用，并消除Csb基因敲除小鼠中p53突变的链偏向性。 - Suppr

Enhanced global genome nucleotide excision repair reduces UV carcinogenesis and nullifies strand bias in p53 mutations in Csb-/- mice.

作者信息

Pines Alex, Hameetman Liesbeth, de Wilde Jillian, Alekseev Sergey, de Gruijl Frank R, Vrieling Harry, Mullenders Leon H F

出版信息

J Invest Dermatol. 2010 Jun;130(6):1746-9. doi: 10.1038/jid.2010.18. Epub 2010 Feb 11.

DOI:10.1038/jid.2010.18

PMID:20147962

Abstract

摘要

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Enhanced global genome nucleotide excision repair reduces UV carcinogenesis and nullifies strand bias in p53 mutations in Csb-/- mice.增强的全基因组核苷酸切除修复可减少紫外线致癌作用，并消除Csb基因敲除小鼠中p53突变的链偏向性。

J Invest Dermatol. 2010 Jun;130(6):1746-9. doi: 10.1038/jid.2010.18. Epub 2010 Feb 11.

Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice.通过突变谱以及在各种DNA修复缺陷小鼠中的诱导动力学分析紫外线诱导的突变型p53斑块与皮肤肿瘤之间的关系。

Carcinogenesis. 2005 Dec;26(12):2123-30. doi: 10.1093/carcin/bgi198. Epub 2005 Jul 28.

Smad4 loss in mouse keratinocytes leads to increased susceptibility to UV carcinogenesis with reduced Ercc1-mediated DNA repair.Smad4 缺失导致小鼠角质细胞对 UV 致癌作用的易感性增加，Ercc1 介导的 DNA 修复减少。

J Invest Dermatol. 2013 Nov;133(11):2609-2616. doi: 10.1038/jid.2013.213. Epub 2013 May 6.

Increased expression of p53 enhances transcription-coupled repair and global genomic repair of a UVC-damaged reporter gene in human cells.p53表达增加可增强人类细胞中紫外线C损伤报告基因的转录偶联修复和全基因组修复。

DNA Repair (Amst). 2007 May 1;6(5):588-601. doi: 10.1016/j.dnarep.2006.11.008. Epub 2006 Dec 28.

p53 protects against skin cancer induction by UV-B radiation.p53可抵御紫外线B辐射诱发的皮肤癌。

Oncogene. 1999 Jul 22;18(29):4247-53. doi: 10.1038/sj.onc.1202789.

Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity.早期p53阳性病灶作为紫外线照射的无毛小鼠肿瘤风险指标：诱导动力学、DNA修复缺陷的影响及p53杂合性

Cancer Res. 2001 Feb 1;61(3):977-83.

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition.科凯恩综合征B型小鼠中缺陷的转录偶联修复与皮肤癌易感性相关。

Cell. 1997 May 2;89(3):425-35. doi: 10.1016/s0092-8674(00)80223-8.

Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches.成纤维细胞生长因子受体 2 单克隆抗体（faricimab）治疗湿性年龄相关性黄斑变性的疗效和安全性：两年的疗效和安全性数据

J Invest Dermatol. 2012 Apr;132(4):1263-71. doi: 10.1038/jid.2011.418. Epub 2011 Dec 22.

Topical thymidine dinucleotide application protects against UVB-induced skin cancer in mice with DNA repair gene (Ercc1)-deficient skin.局部应用胸腺嘧啶二核苷酸可保护DNA修复基因（Ercc1）缺陷型皮肤的小鼠免受紫外线B诱导的皮肤癌侵害。

DNA Repair (Amst). 2009 May 1;8(5):664-71. doi: 10.1016/j.dnarep.2009.01.020. Epub 2009 Mar 4.

Differentiating human keratinocytes are deficient in p53 but retain global nucleotide excision repair following ultraviolet radiation.分化中的人角质形成细胞缺乏p53，但在紫外线辐射后仍保留整体核苷酸切除修复能力。

DNA Repair (Amst). 2005 Sep 28;4(10):1149-59. doi: 10.1016/j.dnarep.2005.06.004.

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The interaction effects of pri-let-7a-1 rs10739971 with PGC and ERCC6 gene polymorphisms in gastric cancer and atrophic gastritis.pri-let-7a-1 rs10739971与PGC及ERCC6基因多态性在胃癌和萎缩性胃炎中的相互作用

PLoS One. 2014 Feb 25;9(2):e89203. doi: 10.1371/journal.pone.0089203. eCollection 2014.

A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer.基于社区的核苷酸切除修复多态性与非黑色素瘤皮肤癌风险的关系研究。

J Invest Dermatol. 2012 May;132(5):1354-62. doi: 10.1038/jid.2012.4. Epub 2012 Feb 16.

Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light.转录偶联修复和细胞凋亡对紫外线诱导的转录相关诱变提供了特异性保护。

Transcription. 2010 Sep-Oct;1(2):95-8. doi: 10.4161/trns.1.2.12788.

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Enhanced global genome nucleotide excision repair reduces UV carcinogenesis and nullifies strand bias in p53 mutations in Csb-/- mice.

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