Antia Ustana, Tingle Malcolm D, Russell Bruce R
School of Pharmacy, University of Auckland, Private Bag 92019, Auckland, New Zealand.
N Z Med J. 2009 Dec 11;122(1307):55-68.
BZP and TFMPP are amphetamine-like recreational drugs and the major active components of 'party pills'. The pharmacodynamic effects of these neurally active drugs are thought to be dependent on their activity at DA and 5-HT receptors and several studies report drug-drug interactions at a pharmacodynamic level. Their metabolism involves the hepatic P450 enzymes CYP2D6, CYP1A2 and CYP3A4 resulting in inhibited metabolism of other drugs and medicines, as well as compromised metabolism in poor metabolisers for CYP2D6. Basic pharmacokinetic properties are described for both BZP and TFMPP when taken alone and in combination. Several studies have shown that these drugs cause several drug-drug interactions.
BZP和TFMPP是类似苯丙胺的消遣性药物，也是“派对药丸”的主要活性成分。这些神经活性药物的药效学作用被认为取决于它们对多巴胺（DA）和5-羟色胺（5-HT）受体的活性，并且有几项研究报告了在药效学水平上的药物相互作用。它们的代谢涉及肝脏细胞色素P450酶CYP2D6、CYP1A2和CYP3A4，这会导致其他药物和药品的代谢受到抑制，以及CYP2D6代谢不良者的代谢受损。文中描述了BZP和TFMPP单独服用及联合服用时的基本药代动力学特性。几项研究表明，这些药物会引发多种药物相互作用。
