Antia Ushtana, Tingle Malcolm D, Russell Bruce R
Ushtana Antia, Research Assistant, School of Pharmacy, University of Auckland, Private Bag 92019, Auckland, New Zealand.
N Z Med J. 2009 Sep 25;122(1303):29-38.
This study explores potential drug-drug interactions between BZP and TFMPP. This was achieved by comparing the metabolism and pharmacokinetics of BZP and TFMPP when taken together with previously published data on their individual metabolism and pharmacokinetics.
Blood and urine samples were collected from seven participants given a combined dose of BZP (100 mg) and TFMPP (30 mg) and analysed by LC-MS in order to quantify the concentrations of BZP, TFMPP, and their major hydroxylated metabolites 3-OH BZP, 4-OH BZP, and 4-OH TFMPP.
The metabolic profiles of both drugs were altered when co-administered. Both BZP and TFMPP lost one metabolite, 3-OH BZP and 4-OH TFMPP, respectively. Some differences in the pharmacokinetic properties of TFMPP were also noted.
Metabolic interactions between BZP and TFMPP are clearly observed in this study along with some changes to the pharmacokinetics of TFMPP. As these drugs are often co-administered, the interactions between them are both relevant and concerning. Awareness of these interactions can assist clinicians in understanding toxicities relating to the co-administration of BZP and TFMPP or other party pill drugs.
本研究探讨了BZP与TFMPP之间潜在的药物相互作用。这是通过将BZP和TFMPP合用时的代谢和药代动力学与先前发表的关于它们各自代谢和药代动力学的数据进行比较来实现的。
从7名服用BZP（100毫克）和TFMPP（30毫克）联合剂量的参与者中采集血液和尿液样本，并通过液相色谱-质谱联用仪（LC-MS）进行分析，以定量BZP、TFMPP及其主要羟基化代谢物3-OH BZP、4-OH BZP和4-OH TFMPP的浓度。
两种药物合用时，它们的代谢谱均发生了改变。BZP和TFMPP分别失去了一种代谢物，即3-OH BZP和4-OH TFMPP。还注意到TFMPP药代动力学特性的一些差异。
本研究清楚地观察到BZP与TFMPP之间的代谢相互作用以及TFMPP药代动力学的一些变化。由于这些药物经常联合使用，它们之间的相互作用既相关又令人担忧。了解这些相互作用有助于临床医生理解与BZP和TFMPP或其他派对药丸药物联合使用相关的毒性。
