Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de Victoria de Málaga, España.
Nutr Metab (Lond). 2010 Jan 15;7:3. doi: 10.1186/1743-7075-7-3.
Adipose tissue is a key regulator of energy balance playing an active role in lipid storage and may be a dynamic buffer to control fatty acid flux. Just like PPARgamma, fatty acid synthesis enzymes such as FASN have been implicated in almost all aspects of human metabolic alterations such as obesity, insulin resistance or dyslipemia. The aim of this work is to investigate how FASN and PPARgamma expression in human adipose tissue is related to carbohydrate metabolism dysfunction and obesity.
The study included eighty-seven patients which were classified according to their BMI and to their glycaemia levels in order to study FASN and PPARgamma gene expression levels, anthropometric and biochemical variables.
The main result of this work is the close relation between FASN expression level and the factors that lead to hyperglycemic state (increased values of glucose levels, HOMA-IR, HbA1c, BMI and triglycerides). The correlation of the enzyme with these parameters is inversely proportional. On the other hand, PPARgamma is not related to carbohydrate metabolism.
We can demonstrate that FASN expression is a good candidate to study the pathophysiology of type II diabetes and obesity in humans.
脂肪组织是能量平衡的关键调节剂，在脂质储存中发挥积极作用，并且可能是控制脂肪酸通量的动态缓冲器。就像 PPARγ 一样，脂肪酸合成酶（如 FASN）几乎与肥胖、胰岛素抵抗或血脂异常等人类代谢改变的所有方面都有关联。本研究的目的是研究人脂肪组织中 FASN 和 PPARγ 的表达与碳水化合物代谢功能障碍和肥胖的关系。
本研究纳入了 87 名患者，根据 BMI 和血糖水平对其进行分类，以研究 FASN 和 PPARγ 基因表达水平、人体测量学和生化变量。
本研究的主要结果是 FASN 表达水平与导致高血糖状态的因素（血糖水平升高、HOMA-IR、HbA1c、BMI 和甘油三酯升高）之间的密切关系。该酶与这些参数的相关性呈反比。另一方面，PPARγ 与碳水化合物代谢无关。
我们可以证明 FASN 表达是研究人类 2 型糖尿病和肥胖的病理生理学的一个很好的候选物。
