Takahashi T, Marcus B, Scheerer R G, Katz M
Department of Obstetrics and Gynecology, Nippon Medical School, Kawasaki, Japan.
Am J Obstet Gynecol. 1991 Apr;164(4):1115-8. doi: 10.1016/0002-9378(91)90598-l.
A rabbit cervix preparation designed to evaluate the effects of locally administered substances and those of prelabor contractility on cervical ripening is described. In one experiment, one of the two cervices was exposed to prostaglandin E2 gel and the contralateral cervix was exposed to plain gel. In another experiment, one cervix was completely isolated from prelabor contractility, whereas the contralateral cervix remained intact. Cervical ripening was assessed by measurement of the stretch modulus and rate of creep 2 days later. Treatment with prostaglandin E2 gel and exposure to prelabor contractility resulted in significant unilateral cervical changes, suggesting that at least part of the prostaglandin E2 effect is locally mediated and that spontaneous prelabor contractility may play a role in cervical preparation for labor. Furthermore, because of its simplicity, this animal preparation can be useful in the investigation of the effects of other locally administered substances on cervical ripening.
本文描述了一种兔宫颈制备方法，用于评估局部给药物质以及分娩前收缩对宫颈成熟的影响。在一项实验中，将两个宫颈中的一个暴露于前列腺素E2凝胶，对侧宫颈暴露于普通凝胶。在另一项实验中，将一个宫颈与分娩前收缩完全隔离，而对侧宫颈保持完整。2天后通过测量拉伸模量和蠕变速率来评估宫颈成熟情况。用前列腺素E2凝胶治疗以及暴露于分娩前收缩导致了明显的单侧宫颈变化，这表明前列腺素E2的作用至少部分是由局部介导的，并且自发的分娩前收缩可能在宫颈为分娩做准备中发挥作用。此外，由于其简单性，这种动物制备方法可用于研究其他局部给药物质对宫颈成熟的影响。
