Owiny J R, Fitzpatrick R J
Department of Veterinary Clinical Sciences, University of Liverpool, England.
Am J Obstet Gynecol. 1990 Aug;163(2):657-60. doi: 10.1016/0002-9378(90)91219-3.
The extensibility ("creep" or strain per minute) and the stretch modulus (stress per unit strain) of strips of cervical tissue were measured in vitro. Intravaginal application of prostaglandin E2 gel led to a fourfold increase in the extensibility (mean +/- SE, 15.45 +/- 0.26 versus 4.23 +/- 0.86 min-1; p less than 0.05) and a twofold reduction in the stretch modulus (mean +/- SE, 0.66 +/- 0.03 versus 1.28 +/- 0.12 N.mm2; p less than 0.0005). This marked increase in the degree of softening occurred in the absence of an increase in uterine activity or changes in plasma progesterone concentrations.
在体外测量了宫颈组织条带的伸展性（“蠕变”或每分钟应变）和拉伸模量（单位应变的应力）。阴道内应用前列腺素E2凝胶导致伸展性增加四倍（平均值±标准误，15.45±0.26对4.23±0.86分钟-1；p<0.05），拉伸模量降低两倍（平均值±标准误，0.66±0.03对1.28±0.12N·mm2；p<0.0005）。这种显著的软化程度增加发生在子宫活动没有增加或血浆孕酮浓度没有变化的情况下。
