Matalliotakis I, Cakmak H, Fragouli Y, Zervoudis S, Neonaki M, Arici A
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.
J BUON. 2009 Oct-Dec;14(4):699-701.
Women with endometriosis have been reported to be at increased risk of developing non-Hodgkin's lymphoma (NHL). The purpose of this article was to investigate the familial risk of NHL in women with endometriosis. We report on 10 cases with endometriosis and positive family history of NHL.
The medical records of 405 women with endometriosis and 200 without endometriosis were retrospectively analysed. All of the cases were diagnosed by laparoscopy. Ten cases of endometriosis having first-degree relatives with NHL are reported.
We found no case with endometriosis and NHL. In contrast, we found 10/405 (2.5%) women with endometriosis and first-degree relatives with NHL. Their mean age was 38.3 years (range 29-46). The main complaint was infertility. The mean age at onset of endometriosis was 32 years (range 22-43). The stages of endometriosis were: stage II (n=4), stage III (n=2) and stage IV (n=4). All of these patients had first-degree relatives with a history of NHL. Five had mothers with NHL, 5 had fathers and one had a sister.
These cases could suggest a link between a family history of NHL and subsequent development of endometriosis in the first-generation women. Moreover, there was no evidence of association between endometriosis and NHL.
据报道，患有子宫内膜异位症的女性患非霍奇金淋巴瘤（NHL）的风险增加。本文旨在研究患有子宫内膜异位症的女性患NHL的家族风险。我们报告了10例患有子宫内膜异位症且有NHL家族史的病例。
对405例患有子宫内膜异位症的女性和200例未患子宫内膜异位症的女性的病历进行回顾性分析。所有病例均通过腹腔镜检查确诊。报告了10例患有子宫内膜异位症且一级亲属患有NHL的病例。
我们未发现患有子宫内膜异位症和NHL的病例。相比之下，我们发现405例患有子宫内膜异位症的女性中有10例（2.5%）的一级亲属患有NHL。她们的平均年龄为38.3岁（范围29 - 46岁）。主要症状是不孕。子宫内膜异位症的平均发病年龄为32岁（范围22 - 43岁）。子宫内膜异位症的分期为：II期（n = 4）、III期（n = 2）和IV期（n = 4）。所有这些患者都有患NHL病史的一级亲属。5人有患NHL的母亲，5人有患NHL的父亲，1人有患NHL的姐妹。
这些病例可能表明NHL家族史与第一代女性随后发生子宫内膜异位症之间存在联系。此外，没有证据表明子宫内膜异位症与NHL之间存在关联。
