Mensah F K, Willett E V, Ansell P, Adamson P J, Roman E
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK.
Am J Epidemiol. 2007 Jan 15;165(2):126-33. doi: 10.1093/aje/kwj361. Epub 2006 Oct 27.
Familial aggregation of non-Hodgkin's lymphoma, and the co-occurrence of non-Hodgkin's lymphoma and other hematologic malignancies within families, provide evidence for genetic or common environmental etiologies for these conditions. The authors analyzed the association between non-Hodgkin's lymphoma risk and family history of hematologic malignancy using a case-control study based in the United Kingdom. The study recruited patients diagnosed with lymphoma during 1998-2001. Results indicated an increased risk of non-Hodgkin's lymphoma for persons with a positive family history of any hematologic malignancy (odds ratio = 1.70, 95% confidence interval: 1.08, 2.69) and particularly of any lymphoma (odds ratio = 2.43, 95% confidence interval: 1.14, 5.19). The authors compared the number of hematologic malignancies among relatives reported by the cases and controls with that expected from the national rates of hematologic malignancy registered in the United Kingdom. Through these comparisons, the authors raise questions about the validity of self-reported family history of hematologic malignancy, especially regarding identification of specific types of hematologic malignancies. Given these reservations, they consider how future epidemiologic studies may contribute to further understanding the role of familial susceptibility in non-Hodgkin's lymphoma.
非霍奇金淋巴瘤的家族聚集性，以及家族中非霍奇金淋巴瘤与其他血液系统恶性肿瘤的共同出现，为这些疾病的遗传或共同环境病因提供了证据。作者利用英国的一项病例对照研究，分析了非霍奇金淋巴瘤风险与血液系统恶性肿瘤家族史之间的关联。该研究招募了在1998 - 2001年期间被诊断为淋巴瘤的患者。结果表明，任何血液系统恶性肿瘤家族史呈阳性的人患非霍奇金淋巴瘤的风险增加（比值比 = 1.70，95%置信区间：1.08，2.69），尤其是任何淋巴瘤家族史呈阳性的人（比值比 = 2.43，95%置信区间：1.14，5.19）。作者将病例组和对照组报告的亲属中血液系统恶性肿瘤的数量与根据英国登记的全国血液系统恶性肿瘤发病率预期的数量进行了比较。通过这些比较，作者对自我报告的血液系统恶性肿瘤家族史的有效性提出了疑问，特别是在特定类型血液系统恶性肿瘤的识别方面。考虑到这些保留意见，他们思考了未来的流行病学研究如何有助于进一步理解家族易感性在非霍奇金淋巴瘤中的作用。
