Samelis G F, Ekmektzoglou K A, Tsiakou A, Konstadoulakis M M
Department of Medical Oncology, Hippocratio General Hospital, Athens, Greece.
J BUON. 2009 Oct-Dec;14(4):717-20.
Melanoma, an aggressive, therapy-resistant malignancy of melanocytes, is the most serious type of skin cancer affecting young and middle-aged people. Therapy for early disease is predominantly surgical, with a minor benefit noted with the use of adjuvant therapy. Management of systemic melanoma is a challenge because of a paucity of active treatment modalities. The authors present the case of a patient with advanced-stage melanoma who underwent surgery for metastatic disease. He then received cisplatin-based combination chemotherapy, with disease stabilization. However, after different regimen modifications complete remission (CR) was finally achieved, until the disease progressed once more. Five years after surgery, the patient is still alive and continuing chemotherapy.
黑色素瘤是一种侵袭性强、对治疗有抗性的黑素细胞恶性肿瘤，是影响中青年人群的最严重的皮肤癌类型。早期疾病的治疗主要是手术，辅助治疗的益处较小。由于缺乏有效的治疗方式，全身性黑色素瘤的管理是一项挑战。作者介绍了一例晚期黑色素瘤患者的病例，该患者因转移性疾病接受了手术。随后他接受了以顺铂为基础的联合化疗，病情得到稳定。然而，在进行了不同的方案调整后最终实现了完全缓解（CR），直到疾病再次进展。手术后五年，患者仍然存活并继续接受化疗。
