State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, PR China 130012.
Langmuir. 2010 Jun 1;26(11):8187-94. doi: 10.1021/la904558h.
A facile layer-by-layer (LbL) assembly method for the fabrication of matrix films capable of coloading and simultaneous release of oppositely charged molecules has been established by using polyampholyte microgels as building blocks. Polyampholyte microgels (named PAH-D-CO(2)) containing amine and carbamate groups were LbL assembled with polyanion poly(sodium 4-styrenesulfonate) (PSS) to produce PAH-D-CO(2)/PSS multilayer films. The successful fabrication of PAH-D-CO(2)/PSS multilayer films was verified by quartz crystal microbalance measurements and cross-sectional scanning electron microscopy. Anionic methyl orange and cationic rhodamine 6G were coloaded into PAH-D-CO(2)/PSS multilayer films because of the electrostatic interaction of these dyes with amine and carbamate groups in the PAH-D-CO(2)/PSS microgel films. The abundance of amine and carbamate groups as well as the swelling capacity of PAH-D-CO(2) microgels guarantees the high loading capacity of the PAH-D-CO(2)/PSS multilayer films toward the anionic and cationic dyes. Methyl orange and rhodamine 6G were simultaneously released from PAH-D-CO(2)/PSS multilayer films when immersing the dye-loaded films into 0.9% normal saline. The releasing behaviors of the polyampholyte microgel films can be tailored by capping the PAH-D-CO(2)/PSS films with barrier layers. The polyampholyte microgel films of PAH-D-CO(2)/PSS are expected to be widely useful as matrixes for coloading oppositely charged functional guest materials such as drugs and even for their controlled release.
一种简便的层层（LbL）组装方法，用于制造能够共载和同时释放带相反电荷分子的基质膜，该方法使用聚两性电解质微凝胶作为构建块。含有胺基和氨基甲酸酯基团的聚两性电解质微凝胶（命名为 PAH-D-CO(2)）与聚阴离子聚（4-苯乙烯磺酸钠）（PSS）进行 LbL 组装，以生成 PAH-D-CO(2)/PSS 多层膜。通过石英晶体微天平测量和横截面扫描电子显微镜验证了 PAH-D-CO(2)/PSS 多层膜的成功制备。由于这些染料与 PAH-D-CO(2)/PSS 微凝胶膜中的胺基和氨基甲酸酯基团之间的静电相互作用，阴离子甲基橙和阳离子罗丹明 6G 被共载入 PAH-D-CO(2)/PSS 多层膜中。PAH-D-CO(2)微凝胶中胺基和氨基甲酸酯基团的丰富程度以及 PAH-D-CO(2)微凝胶的溶胀能力保证了 PAH-D-CO(2)/PSS 多层膜对阴离子和阳离子染料的高负载能力。当将负载有染料的膜浸入 0.9%生理盐水时，甲基橙和罗丹明 6G 从 PAH-D-CO(2)/PSS 多层膜中同时释放。通过用阻挡层封闭 PAH-D-CO(2)/PSS 膜，可以调整聚两性电解质微凝胶膜的释放行为。PAH-D-CO(2)/PSS 的聚两性电解质微凝胶膜有望广泛用作共载带相反电荷的功能客体材料（如药物）的基质，甚至可以用于它们的控制释放。
