基于水解聚两性电解质的层层组装多层膜在宽时间范围内的可调降解
Tunable disintegration of layer-by-layer assembly multilayer films based on hydrolytical-polybetaine at wide-range time.
机构信息
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science & Engineering, Zhejiang University, Hangzhou, Zhejiang, China.
出版信息
J Colloid Interface Sci. 2011 Sep 1;361(1):122-8. doi: 10.1016/j.jcis.2011.05.049. Epub 2011 May 23.
A cationic hydrolytical-polycarboxybetaine (HPCB), poly(N-ethyl acetate-4-vinylpyridinium bromide) was synthesized by incorporating ester group into the side chain of polycarboxybetaine (PCB). The hydrolytic behaviors of HPCB samples in pH 7.4 phosphate buffer saline (PBS) were investigated by FT-IR and (1)H NMR. The layer-by-layer (LbL) assembly of HPCB/poly (sodium 4-styrenesulfonate) PSS and the disintegration of HPCB/PSS multilayer films were monitored by UV-vis absorption spectroscopy, quartz crystal microbalance (QCM) and atomic force microscopy (AFM). The disintegrated behavior of multilayer films was studied in detail by changing the cationic degree of HPCB and the pH of the immersion solution (PBS) in the disintegration process. The disintegration time of HPCB/PSS multilayer films could be controlled widely from 2 min to 30 days in PBS.
一种阳离子水解-聚羧酸甜菜碱（HPCB），聚（N-乙基乙酸盐-4-乙烯基溴化吡啶），是通过在聚羧酸甜菜碱（PCB）的侧链中引入酯基合成的。通过傅里叶变换红外光谱（FT-IR）和（1）H NMR 研究了 HPCB 样品在 pH 7.4 磷酸盐缓冲盐水（PBS）中的水解行为。通过紫外可见吸收光谱、石英晶体微天平（QCM）和原子力显微镜（AFM）监测了 HPCB/聚（4-苯乙烯磺酸钠）PSS 的层层（LbL）组装和 HPCB/PSS 多层膜的崩解。通过改变 HPCB 的阳离子度和崩解过程中浸泡溶液（PBS）的 pH 值，详细研究了多层膜的崩解行为。在 PBS 中，HPCB/PSS 多层膜的崩解时间可以从 2 分钟到 30 天广泛控制。
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