Division of Chemical and Biomolecular Engineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459.
Langmuir. 2010 Jun 1;26(11):8959-65. doi: 10.1021/la904751q.
We demonstrate a simple synthetic strategy for the fabrication of single-phase rare earth (RE) doped gadolinium oxide (Gd(2)O(3):RE where RE = terbium (Tb), ytterbium (Yb), and erbium (Er)) nanorods (NRs) as multimodal imaging probes. The NRs are ultranarrow and exhibit both emission and magnetic characteristics. The Tb-doped and Yb/Er-codoped Gd(2)O(3) NRs exhibit down- and up-conversion fluorescence respectively, and also exhibit paramagnetism. Importantly, these codoped NRs possess excellent magnetic characteristics, as shown in their longitudinal relaxation time (T1) -weighted image contrast, which is closer to that of commercial Gadovist for magnetic resonance imaging (MRI) applications. This property opens up new avenues in the development of contrast agents.
我们展示了一种简单的合成策略，用于制备单相稀土（RE）掺杂氧化钆（Gd（2）O（3）：RE，其中 RE = 铽（Tb）、镱（Yb）和铒（Er））纳米棒（NRs）作为多模态成像探针。这些 NRs 非常狭窄，具有发射和磁性特征。Tb 掺杂和 Yb/Er 共掺杂 Gd（2）O（3）NRs 分别表现出下转换和上转换荧光，并且还表现出顺磁性。重要的是，这些共掺杂 NRs 具有优异的磁性特性，如纵向弛豫时间（T1）加权图像对比度所示，这更接近用于磁共振成像（MRI）应用的商业 Gadovist。这一特性为造影剂的开发开辟了新途径。
