钯催化的苯乙烯分子间氨基氟化反应。
Palladium-catalyzed intermolecular aminofluorination of styrenes.
机构信息
State Key Laboratory of Organometallics Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China, 200032.
出版信息
J Am Chem Soc. 2010 Mar 10;132(9):2856-7. doi: 10.1021/ja909716k.
A novel palladium-catalyzed intermolecular aminofluorination of styrenes, with N-fluorobenzenesulfonimide (NFSI) functioning not only as a fluorinating reagent but also as an aminating reagent, has been developed. The reaction afforded vicinal fluoroamine products with very high regioselectivity. This transformation may involve fluoropalladation of styrene as a key step for C-F bond formation. The bidental nitrogen ligand is crucial to achieving the transformation successfully.
一种新型的钯催化的苯乙烯分子间氨基氟化反应已经被开发出来，其中 N-氟苯磺酰胺（NFSI）不仅作为氟化试剂，还作为氨基化试剂。该反应以非常高的区域选择性得到顺式氟胺产物。这种转化可能涉及苯乙烯的氟钯化作为 C-F 键形成的关键步骤。双齿氮配体对于成功实现转化至关重要。
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