Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
Annu Rev Physiol. 2010;72:273-96. doi: 10.1146/annurev-physiol-021909-135744.
The gastric parietal cell was the first system where a regulated membrane recycling hypothesis was proposed as the principal means for moving molecular transporters between cellular compartments. Upon stimulation, massive membrane flow from an endosomal compartment of tubulovesicle membranes to the apical secretory surface places the ATP-driven pumps in position to secrete a solution of strong acid in collaboration with several other membrane transporters. This review focuses on the membrane recycling pathway and proteins that support the recruitment and redistribution of H,K-ATPase-rich membranes, including those involved in signal transduction, membrane targeting, docking, and fusing, in addition to the integral role of the actin cytoskeleton and its associated proteins in the process of membrane recycling. Although much of the evidence discussed here comes from parietal cell studies, other physiological transport systems, as well as less complex cellular and in vitro models, are examined and cited for generality of principle.
壁细胞是第一个提出受调控的膜循环假说的系统，该假说被认为是分子转运蛋白在细胞区室之间移动的主要方式。受到刺激后，大量的膜从管状囊泡膜的内体区室流向顶端分泌表面，使 ATP 驱动的泵能够与其他几种膜转运蛋白一起分泌强酸溶液。本综述重点介绍了膜循环途径和支持募集和再分配富含 H,K-ATP 酶的膜的蛋白质，包括参与信号转导、膜靶向、对接和融合的蛋白质，以及肌动蛋白细胞骨架及其相关蛋白在膜循环过程中的整体作用。虽然这里讨论的大部分证据来自壁细胞研究，但也检查和引用了其他生理转运系统以及更简单的细胞和体外模型，以证明其原理的普遍性。
