Department of Physiology and Biophysics, The Water and Salt Research Center, Aarhus University, Aarhus C, Denmark.
Annu Rev Physiol. 2010;72:377-93. doi: 10.1146/annurev-physiol-021909-135825.
Renal tubular epithelial cells receive hormonal input that regulates volume and electrolyte homeostasis. In addition, numerous intrarenal, local signaling agonists have appeared on the stage of renal physiology. One such system is that of intrarenal purinergic signaling. This system involves all the elements necessary for agonist-mediated intercellular communication. ATP is released from epithelial cells, which activates P2 receptors in the apical and basolateral membrane and thereby modulates tubular transport. Termination of the signal is conducted via the breakdown of ATP to adenosine. Recent far-reaching advances indicate that ATP is often used as a local transmitter for classical sensory transduction. This transmission apparently also applies to sensory functions in the kidney. Locally released ATP is involved in sensing of renal tubular flow or in detecting the distal tubular load of NaCl at the macula densa. This review describes the relevant aspects of local, intrarenal purinergic signaling and outlines its integrative concepts.
肾小管上皮细胞接受激素输入，调节体积和电解质稳态。此外，许多肾内局部信号激动剂已经出现在肾生理舞台上。其中一个系统是肾内嘌呤能信号系统。该系统涉及激动剂介导细胞间通讯所需的所有要素。ATP 从上皮细胞释放，激活顶端和基底外侧膜中的 P2 受体，从而调节管状运输。信号的终止是通过 ATP 分解为腺苷来进行的。最近的深远进展表明，ATP 通常被用作经典感觉转导的局部递质。这种传递显然也适用于肾脏的感觉功能。局部释放的 ATP 参与肾小管流的感知或在致密斑处检测远端管状 NaCl 的负载。这篇综述描述了局部、肾内嘌呤能信号的相关方面，并概述了其综合概念。
