Department of Biomaterials, Institute for Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Clin Implant Dent Relat Res. 2010 Mar;12(1):39-47. doi: 10.1111/j.1708-8208.2008.00128.x.
Recently, a new implant surface texture, featuring application of nanometer-scale calcium phosphate has been shown to enhance early bone fixation and formation in preclinical studies and in human histomorphometric studies, which may be beneficial in immediate loading situations.
The purpose of the present prospective clinical study was to, during 1 year, clinically and radiographically evaluate a nanometer scale surface modified implant placed for immediate loading of fixed prostheses in both maxillary and mandibular regions.
Thirty-five out of 38 patients who needed implant treatment and met inclusion criteria agreed to participate in the study and were consecutively enrolled. Surgical implant placement requirements consisted of a final torque of a least 25 Ncm prior to final seating and an implant stability quotient above 55. A total of 102 NanoTite PREVAIL (NTP) implants (BIOMET 3i, Palm Beach Gardens, FL, USA) (66 maxillary and 36 mandibular) were placed by one investigator, and the majority of these were placed in posterior regions (65%) and in soft bone (69%). A total of 44 prosthetic constructions were evaluated consisting of 14 single-tooth restorations, 26 fixed partial dentures, and four complete fixed restorations. All provisional constructions were delivered within 1 hour, and the final constructions placed after 4 months. Implants were monitored for clinical and radiographic outcomes at follow-up examinations scheduled for 3, 6, and 12 months.
Of the 102 study implants, one implant failed. The simple cumulative survival rate value at 1 year was 99.2%. The average marginal bone resorption was 0.37 mm (SD 0.39) during the first year in function. According to the success criteria of Albrektsson and Zarb, success grade 1 was found with 93% of the implants.
Although limited to the short follow-up, immediate loading of NanoTite Prevail implants seems to be a viable option in implant rehabilitation, at least when a good initial fixation is achieved.
最近，一种新的植入物表面纹理，应用纳米级磷酸钙，已被证明在临床前研究和人体组织形态计量学研究中增强早期骨固定和形成，这在即刻负重情况下可能是有益的。
本前瞻性临床研究的目的是在 1 年内临床和放射学评估纳米级表面改性植入物在上下颌即刻负重固定义齿中的应用。
38 名需要接受种植治疗并符合纳入标准的患者中有 35 名同意参加研究，并连续入组。手术植入物放置要求为最终扭矩至少为 25 Ncm，然后最终就位，种植体稳定性指数（ISQ）超过 55。由一位研究者共植入 102 个 NanoTite PREVAIL（NTP）种植体（BIOMET 3i，Palm Beach Gardens，FL，USA）（66 个上颌和 36 个下颌），其中大部分放置在后牙区（65%）和软骨质区（69%）。共评估了 44 个修复体结构，包括 14 个单牙修复体、26 个固定局部义齿和 4 个全固定修复体。所有临时修复体在 1 小时内交付，最终修复体在 4 个月后放置。在 3、6 和 12 个月的随访检查中，对植入物的临床和放射学结果进行监测。
在 102 个研究植入物中，有 1 个植入物失败。1 年时简单累积生存率值为 99.2%。在功能的第一年，平均边缘骨吸收为 0.37 毫米（SD 0.39）。根据 Albrektsson 和 Zarb 的成功标准，93%的植入物为 1 级成功。
尽管随访时间有限，但 NanoTite Prevail 植入物的即刻负重似乎是一种可行的选择，至少在获得良好的初始固定时是这样。
