血清白介素-10 的产生与血液透析终末期肾病患者对促红细胞生成素的敏感性。

Production of interleukin-10 in serum and erythropoietin sensitivity in ESRD patients on hemodialysis.

机构信息

Clinical Pathology and Internal Medicine Departments, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

出版信息

Int J Lab Hematol. 2010 Oct;32(5):524-9. doi: 10.1111/j.1751-553X.2009.01218.x. Epub 2010 Feb 9.

DOI:10.1111/j.1751-553X.2009.01218.x

PMID:20148986

Abstract

One of the clinical consequences of aberrant cytokines production in patients with end stage renal disease (ESRD) may be impaired erythropoiesis. To determine the interleukin (IL)-10 levels in ESRD patients on regular hemodialysis (HD) with good and poor response to recombinant human erythropoietin (Epo). Two groups of ESRD-HD patients were evaluated; 48 high epo HD patients and 32 low epo HD patients were evaluated for some laboratory tests and Interleukin-10 by ELISA. The production of IL-10 is decreased in HD with low epo group than high epo group 32.4 +/- 7.9 vs. 45 +/- 6.9 pg/ml (P < 0.001). IL-10 level is well correlated with CRP, ESR, Ferritin, Epo dose, and EPO/Hb ratio in ESRD-HD patients. These findings suggest that IL-10 is playing a part in affecting the response to EPO, even in the absence of any obvious infection or inflammatory condition.

摘要

终末期肾病（ESRD）患者异常细胞因子产生的临床后果之一可能是红细胞生成受损。为了确定定期接受重组人红细胞生成素（Epo）治疗的 ESRD 患者中白细胞介素（IL）-10 的水平，对其反应良好和反应不佳的患者。评估了两组 ESRD-HD 患者；对 48 例高 epo HD 患者和 32 例低 epo HD 患者进行了一些实验室检查和 ELISA 检测白细胞介素-10。低 epo 组 HD 中 IL-10 的产生低于高 epo 组 32.4 +/- 7.9 对 45 +/- 6.9 pg/ml（P < 0.001）。IL-10 水平与 ESRD-HD 患者的 CRP、ESR、铁蛋白、Epo 剂量和 EPO/Hb 比值密切相关。这些发现表明，IL-10 在影响 EPO 反应中发挥作用，即使在没有任何明显感染或炎症的情况下也是如此。