Min Hao, Wei-hong Zhao
Department of Obstetrics and Gynecology, Shanxi Medical University Second Hospital, Taiyuan, Shanxi, China.
J Obstet Gynaecol Res. 2009 Oct;35(5):918-25. doi: 10.1111/j.1447-0756.2009.01045.x.
To investigate the expressions of signal transducer and activator of transcription 3 (Stat3) and tyrosine-activated Stat3 (p-Stat3) in epithelial ovarian carcinoma (EOC) and their relationships with clinical pathological parameters or prognosis.
Immunohistochemical methods were used to detect the expressions of Stat3 and p-Stat3 in EOC, benign ovarian tumors and normal ovarian tissues, after which an analysis of results with clinical pathological or prognosis was given.
The expressions of Stat3 and p-Stat3 in EOC were significantly higher than in normal ovarian epithelial tissues or benign ovarian tumor tissues (P < 0.0125) and the expression of Stat3 protein was highly correlated with the expression of p-Stat3 protein (P < 0.01). The positive rate of Stat3 in stages of III and IV (96.9%) was significantly higher than in stages of I and II (72.2%) (P < 0.05). Meanwhile, p-Stat3 expression was significantly correlated with disease stage, degree of differentiation and lymph node metastasis. Along with higher clinical stage (P < 0.05), p-Stat3 expression was gradually increased. The p-Stat3 expression was negatively correlated with the prognosis of EOC patients (P < 0.01).
Overexpression and overactivation of Stat3 was found in EOC tissues, and the constitutive activation of Stat3 signaling pathway may play an important role in the invasion and prognosis of EOC.
探讨信号转导与转录激活因子3（Stat3）及酪氨酸磷酸化激活的Stat3（p-Stat3）在上皮性卵巢癌（EOC）中的表达及其与临床病理参数和预后的关系。
采用免疫组织化学方法检测EOC、卵巢良性肿瘤及正常卵巢组织中Stat3和p-Stat3的表达，并对结果进行临床病理及预后分析。
EOC中Stat3和p-Stat3的表达显著高于正常卵巢上皮组织或卵巢良性肿瘤组织（P<0.0125），且Stat3蛋白表达与p-Stat3蛋白表达高度相关（P<0.01）。Ⅲ、Ⅳ期Stat3阳性率（96.9%）显著高于Ⅰ、Ⅱ期（72.2%）（P<0.05）。同时，p-Stat3表达与疾病分期、分化程度及淋巴结转移显著相关。随着临床分期升高（P<0.05），p-Stat3表达逐渐增加。p-Stat3表达与EOC患者预后呈负相关（P<0.01）。
EOC组织中存在Stat3的过表达及过度激活，Stat3信号通路的组成性激活可能在EOC的侵袭及预后中起重要作用。
