红细胞脂质的年龄相关变化。
Age-related changes in red blood cell lipids.
作者信息
Prisco D, Rogasi P G, Paniccia R, Abbate R, Gensini G F
机构信息
Clinica Medica I, University of Florence, Italy.
出版信息
Angiology. 1991 Apr;42(4):316-22. doi: 10.1177/000331979104200409.
Red blood cell (RBC) lipid composition was investigated in 81 healthy subjects aged twenty to sixty-nine years, having similar dietary habits, and living in the same geographic area in order to search for changes referable to aging. A significant increase in RBC cholesterol and total phospholipid content with aging was found (p less than 0.001), whereas no differences were observed in cholesterol/phospholipid molar ratio. Significant increases in palmitic acid 16:0 esterified in phosphatidylcholine and in stearic acid 18:0 esterified in phosphatidylethanolamine (p less than 0.001) were observed with aging. Moreover, a decrease in 18:2 n6 was observed in all three phosphoglyceride fractions investigated (p less than 0.001). These results suggest that modifications in RBC lipid composition occur with aging, possibly causing a reduction of membrane fluidity.
为了探寻与衰老相关的变化，我们对81名年龄在20至69岁之间、饮食习惯相似且生活在同一地理区域的健康受试者的红细胞（RBC）脂质组成进行了研究。结果发现，随着年龄增长，红细胞胆固醇和总磷脂含量显著增加（p<0.001），而胆固醇/磷脂摩尔比未观察到差异。随着年龄增长，观察到磷脂酰胆碱中酯化的棕榈酸16:0和磷脂酰乙醇胺中酯化的硬脂酸18:0显著增加（p<0.001）。此外，在所研究的所有三种磷酸甘油酯组分中均观察到18:2 n6减少（p<0.001）。这些结果表明，红细胞脂质组成会随着衰老而发生改变，可能导致膜流动性降低。
Zotero 插件