血小板脂质组成的年龄相关变化。

Age related changes in platelet lipid composition.

作者信息

Prisco D, Rogasi P G, Matucci M, Paniccia R, Abbate R, Gensini G F, Serneri G G

出版信息

Thromb Res. 1986 Nov 15;44(4):427-37. doi: 10.1016/0049-3848(86)90321-x.

Abstract

Platelet lipid composition was investigated in 52 healthy subjects aged 20 to 68 years with similar dietary habits and living in a narrow geographic area in order to search possible changes referrable to aging. No significant variations were observed when platelet cholesterol, total phospholipids and different phospholipid fractions were considered, whereas cholesterol/phospholipid (C/PL) molar ratio significantly increased with aging (p less than 0.01). Moreover, a significant increase in 16:0 + 16:1 fatty acids was found in phosphatidylcholine (PC) and in sphingomyelin (SP) (r = 0.62, p less than 0.001 and r = 0.30, p less than 0.05 respectively) and a decrease in 18:2 n6 in the phospholipid fractions considered (at least p less than 0.05). These results indicate that modifications in platelet lipid composition occur with aging and that they could affect platelet functions so playing a role in the onset of atherosclerosis and in thrombotic phenomena occurring with increasing frequency in the elderly.

摘要

对52名年龄在20至68岁之间、饮食习惯相似且生活在狭窄地理区域的健康受试者的血小板脂质组成进行了研究，以探寻可能与衰老相关的变化。当考虑血小板胆固醇、总磷脂和不同磷脂组分时，未观察到显著差异，而胆固醇/磷脂（C/PL）摩尔比随衰老显著增加（p<0.01）。此外，在磷脂酰胆碱（PC）和鞘磷脂（SP）中发现16:0 + 16:1脂肪酸显著增加（r = 0.62，p<0.001；r = 0.30，p<0.05），且在所考虑的磷脂组分中18:2 n6减少（至少p<0.05）。这些结果表明，血小板脂质组成随衰老发生改变，且这些改变可能影响血小板功能，从而在动脉粥样硬化的发生以及老年人中日益频繁出现的血栓形成现象中发挥作用。