Joliat T L, Weber R W
Dept of Medicine, University of Tennessee Health Science Center, Memphis.
Ann Allergy. 1991 Apr;66(4):301-4.
A 24-year-old white female laboratory technician developed recurrent rhinoconjunctivitis and wheezing immediately following repeated exposure to purified lyophilized bovine serum albumin (BSA). Prick and titrated intradermal skin tests revealed strongly positive results in the patient and negative results in normal controls. A titrated double-blind, placebo-controlled bronchial inhalation challenge with an aqueous BSA solution was positive at 10 mg/mL. Use of an albuterol metered dose inhaler and avoidance of laboratory exposure to BSA have resulted in resolution of symptoms. These results are consistent with an IgE-mediated mechanism, and this case represents the first reported instance of occupational asthma and rhinoconjunctivitis to inhaled BSA powder.
一名24岁的白人女性实验室技术员在反复接触纯化的冻干牛血清白蛋白（BSA）后，立即出现复发性鼻结膜炎和喘息症状。点刺试验和皮内滴定试验显示，该患者结果呈强阳性，而正常对照者结果为阴性。用BSA水溶液进行的滴定双盲、安慰剂对照支气管吸入激发试验在浓度为10 mg/mL时呈阳性。使用沙丁胺醇定量气雾剂并避免在实验室接触BSA后，症状得到缓解。这些结果与IgE介导的机制相符，该病例是首例报告的因吸入BSA粉末导致职业性哮喘和鼻结膜炎的病例。
