School of Sport Performing Arts and Leisure, University of Wolverhampton, Walsall, West Midlands, United Kingdom.
Clin Exp Rheumatol. 2009 Nov-Dec;27(6):985-8.
It has been frequently stated that rheumatoid cachexia (RC) associates with increased cardiovascular risk; however, no studies to date have investigated this. The aim of this study was to investigate the association of RC with multiple novel and classical cardiovascular disease (CVD) risk factors and the presence of established CVD in rheumatoid arthritis (RA).
A total of 34 RA patients with RC (RA+RC) were identified from a database of 400 RA patients using published RC criteria and compared to the remaining patients (RA-RC) who did not fulfil RC criteria. All patients were assessed for fat and fat-free mass, albumin (indicator of catabolism), disease activity/severity, novel and classical risk CVD factors and established CVD.
Fat-free mass (kg) and albumin (g/L) were significantly decreased in RA+RC vs. RA-RC patients: 37.3(33.9-41.6) vs. 45.9(41.2-55.5), p<0.001 and 39.6 + or - 6.7 vs. 42.4 + or - 4.9, p=0.001). Percent body fat was not significantly different. No significant differences were detected in either the classical or novel CVD risk factors, 10-year CVD risk or the prevalence of established CVD.
RC does not appear to be associated with worse CVD profile in RA patients, but this needs to be confirmed in prospective studies.
有研究频繁指出类风湿性恶病质（RC）与心血管风险增加相关；然而，目前尚无研究对此进行调查。本研究旨在探讨 RC 与多种新型和经典心血管疾病（CVD）风险因素以及类风湿关节炎（RA）中已确立的 CVD 的相关性。
使用发表的 RC 标准，从 400 例 RA 患者的数据库中确定了 34 例 RC 伴 RA（RA+RC）患者，并将其与未符合 RC 标准的其余患者（RA-RC）进行比较。对所有患者进行脂肪和去脂体重、白蛋白（代谢的指标）、疾病活动/严重程度、新型和经典 CVD 风险因素以及已确立的 CVD 的评估。
与 RA-RC 患者相比，RA+RC 患者的去脂体重（kg）和白蛋白（g/L）显著降低：37.3（33.9-41.6）与 45.9（41.2-55.5），p<0.001；39.6 ± 6.7 与 42.4 ± 4.9，p=0.001）。体脂百分比无显著差异。新型和经典 CVD 风险因素、10 年 CVD 风险或已确立 CVD 的患病率均无显著差异。
RC 似乎与 RA 患者的 CVD 特征无明显相关性，但这需要前瞻性研究加以证实。
Zotero 插件