单纯疱疹病毒检测与新生儿和婴儿的住院时间。
Herpes simplex virus testing and hospital length of stay in neonates and young infants.
机构信息
Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
出版信息
J Pediatr. 2010 May;156(5):738-43. doi: 10.1016/j.jpeds.2009.11.079. Epub 2010 Feb 10.
OBJECTIVE
To examine whether ordering testing of cerebrospinal fluid (CSF) for herpes simplex virus (HSV) by polymerase chain reaction (PCR) in neonates and young infants is associated with increased hospital length of stay (LOS) or increased hospital charges.
STUDY DESIGN
This retrospective cohort study enrolled infants age <or=56 days who underwent lumbar puncture in the emergency department in 2005-2006. The primary "exposure" was CSF HSV PCR, and the primary outcomes were LOS and hospital charges.
RESULTS
CSF HSV PCR was performed in 282 of 889 eligible infants (31.7%). The median test turnaround time was 22 hours. The median LOS was 2 days, and median hospital charge was $10 166. In multivariate analysis, CSF HSV PCR testing was associated with a LOS increase of 28% for infants age <or=28 days and 39% for infants age 29-56 days. LOS increased by 22% for every 12-hour increase in test turnaround time. CSF HSV PCR testing was associated with a 41% increase in hospital charges.
CONCLUSIONS
In infants evaluated by lumbar puncture in the emergency department, CSF HSV PCR testing was associated with a significantly longer LOS and higher hospital charges.
目的
探讨聚合酶链反应（PCR）检测新生儿和婴幼儿单纯疱疹病毒（HSV）脑脊液（CSF）是否与住院时间延长（LOS）或住院费用增加有关。
研究设计
本回顾性队列研究纳入了 2005 年至 2006 年在急诊科行腰椎穿刺的年龄<56 天的婴儿。主要“暴露”为 CSF HSV PCR，主要结局为 LOS 和住院费用。
结果
889 名符合条件的婴儿中，282 名（31.7%）进行了 CSF HSV PCR 检测。中位检测周转时间为 22 小时。中位 LOS 为 2 天，中位住院费用为 10166 美元。多变量分析显示，CSF HSV PCR 检测与年龄<28 天的婴儿 LOS 增加 28%和年龄 29-56 天的婴儿 LOS 增加 39%相关。检测周转时间每增加 12 小时，LOS 增加 22%。CSF HSV PCR 检测与住院费用增加 41%相关。
结论
在急诊科行腰椎穿刺评估的婴儿中，CSF HSV PCR 检测与 LOS 显著延长和住院费用增加有关。
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