通过自噬进行抗原加工——不再仅仅为 MHC Ⅱ类分子呈递？
Antigen processing via autophagy--not only for MHC class II presentation anymore?
机构信息
Viral Immunobiology, Institute of Experimental Immunology, University Hospital of Zürich, Switzerland.
出版信息
Curr Opin Immunol. 2010 Feb;22(1):89-93. doi: 10.1016/j.coi.2010.01.016. Epub 2010 Feb 9.
Abstract
T cells monitor intracellular and extracellular protein composition via proteolytic products that are displayed to them on major histocompatibility complex (MHC) molecules. For this purpose it has been documented that MHC class II molecules, which were originally thought to just display lysosomal products of endocytosed proteins to CD4(+) helper T cells, can also present intracellular substrates of autophagic pathways. This has triggered the interest of immunologists into the role of autophagy in antigen processing in general, and recently additional autophagic mechanisms for intracellular and extracellular antigen processing onto MHC class I molecules for presentation to CD8(+) cytolytic T cells have been revealed. Here, I will review the contribution of autophagy for MHC class I and class II antigen processing and presentation to T cells.
摘要
T 细胞通过主要组织相容性复合体 (MHC) 分子上呈现的蛋白水解产物来监测细胞内和细胞外的蛋白组成。为此，有文献记载，MHC Ⅱ类分子最初被认为只将内吞蛋白的溶酶体产物呈递给 CD4(+)辅助 T 细胞，也可以呈现自噬途径的细胞内底物。这激发了免疫学家对自噬在一般抗原加工中的作用的兴趣，最近还揭示了其他自噬机制，用于将细胞内和细胞外的抗原加工到 MHC Ⅰ类分子上，以供 CD8(+)细胞毒性 T 细胞呈递。在这里，我将回顾自噬对 MHC Ⅰ类和Ⅱ类抗原加工和呈递给 T 细胞的贡献。
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