Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Mol Immunol. 2019 Sep;113:2-5. doi: 10.1016/j.molimm.2017.10.021. Epub 2017 Nov 8.
Major histocompatibility complex (MHC) class I molecules present peptide antigens to MHC class I-restricted CD8 T lymphocytes. The peptides loaded onto MHC class I molecules are typically derived from cytosolic antigens, which includes both self and foreign proteins. In addition to this classical MHC class I antigen presentation pathway, some cell types, especially dendritic cells can present antigens from exogenous sources to MHC class I-restricted CD8 T cells, in a process called cross-presentation. A variety of cellular processes, including endocytosis, vesicle trafficking, and autophagy, play critical roles in these antigen presentation pathways. In this review article, we discuss the role of autophagy, an intracellular degradation system that delivers cytoplasmic constituents to lysosomes, in MHC class I-restricted antigen presentation. A mechanistic understanding of the role of autophagy-related proteins in MHC class I restricted antigen presentation may guide future efforts in manipulating autophagy to prevent or treat human disease.
主要组织相容性复合体 (MHC) Ⅰ类分子将肽抗原呈递给 MHC Ⅰ类限制性 CD8 T 淋巴细胞。加载到 MHC Ⅰ类分子上的肽通常来自胞质抗原，包括自身和外源蛋白。除了这种经典的 MHC Ⅰ类抗原呈递途径外，某些细胞类型，特别是树突状细胞，可在外源来源的抗原呈递给 MHC Ⅰ类限制性 CD8 T 细胞，这一过程称为交叉呈递。多种细胞过程，包括内吞作用、囊泡运输和自噬，在这些抗原呈递途径中发挥关键作用。在这篇综述文章中，我们讨论了自噬在 MHC Ⅰ类限制性抗原呈递中的作用，自噬是一种将细胞质成分递送到溶酶体的细胞内降解系统。对自噬相关蛋白在 MHC Ⅰ类限制性抗原呈递中的作用的机制理解可能会指导未来操纵自噬以预防或治疗人类疾病的努力。
