Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.
Microvasc Res. 2010 May;79(3):169-73. doi: 10.1016/j.mvr.2010.02.003. Epub 2010 Feb 10.
Numerous studies have suggested the presence of precursor cells in various tissues and organs with potential to differentiate into endothelial and mural cells, and contribute to blood vessel formation in different physiological and pathological circumstances. Although there is still a lack of consensus in the field regarding the origin, and phenotypic and functional characteristics of putative vascular progenitor cell populations, all agree that further studies are needed to fully explore and exploit their great potential as cell therapy for vascular diseases, as modulators of postnatal blood vessel formation, and as disease biomarkers. Herein, we will review the phenotypic and functional characteristics of endothelial progenitor/precursor cell types thought to be derived from the hematopoietic and vascular systems and contribute to postnatal blood vessel formation, and discuss their potential lineage relationships.
大量研究表明，各种组织和器官中存在具有分化为内皮细胞和壁细胞潜能的前体细胞，并且在不同的生理和病理情况下有助于血管形成。尽管在该领域对于假定的血管祖细胞群体的起源、表型和功能特征仍缺乏共识，但所有人都同意需要进一步研究来充分探索和利用它们作为血管疾病的细胞治疗、作为成体血管形成的调节剂以及作为疾病生物标志物的巨大潜力。在此，我们将回顾被认为源自造血系统和血管系统并有助于成体血管形成的内皮祖细胞/前体细胞类型的表型和功能特征，并讨论它们的潜在谱系关系。
