Department of Neurobiology Care Sciences and Society (NVS), Division of KI-Alzheimer Disease Research Center, Karolinska Institutet, NOVUM plan 5, S-141 86 Stockholm, Sweden.
Physiol Behav. 2010 Apr 19;99(5):663-8. doi: 10.1016/j.physbeh.2010.01.038. Epub 2010 Feb 10.
The impact of invasive experimental procedures on perceived stress and pain may be dependent on both physical and social environmental conditions. The aim of this study was to evaluate the effects of a physically and a socially enriched environment on the need for pain relief following painful experimental procedures. A non-invasive method to administer analgesics post-operatively is by means of self-administration which is a feasible objective method to measure perceived pain during the post-operative recovery period. In the present study eight groups of mice housed in different conditions underwent the surgical procedure of caecal manipulation or only exposure to anaesthesia. After surgery the mice were given the choice to self-administer an analgesic available in one of their water bottles during two post-operative weeks. It was shown that socially enriched mice drank i.e. self-administered, less from the analgesic containing water than the non-enriched and socially deprived groups. Mice that underwent operation self-administered more analgesic than mice that received only anaesthesia without operation. The findings indicate that the recovery environment can contribute positively to attenuate the need for pain relief in animals submitted to invasive procedures.
侵入性实验程序对感知压力和疼痛的影响可能取决于生理和社会环境条件。本研究的目的是评估物理和社会丰富环境对疼痛实验程序后止痛需求的影响。术后给予镇痛药的非侵入性方法是通过自我给药，这是一种可行的客观方法来测量术后恢复期的感知疼痛。在本研究中，八组在不同条件下饲养的小鼠接受盲肠操作的手术程序或仅接受麻醉暴露。手术后，小鼠可以选择在两个术后周内从一个水瓶中自行服用一种可用的镇痛药。结果表明，与非丰富和社会剥夺组相比，社会丰富的小鼠从含镇痛药的水中饮用（即自我给药）的量较少。接受手术的小鼠自我给药的镇痛药多于仅接受麻醉而未接受手术的小鼠。研究结果表明，恢复环境可以积极有助于减轻接受侵入性程序的动物对缓解疼痛的需求。
