Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA.
Neuroscience. 2010 Apr 28;167(1):11-20. doi: 10.1016/j.neuroscience.2010.02.002. Epub 2010 Feb 8.
Consumption beyond homeostatic needs, referred to here as reward-based feeding behavior, is a central contributor to the current obesity epidemic worldwide. Importantly, reward-based feeding can be driven by palatability, the taste and texture of the food, as well as cues associated with the consumption of palatable foods. The hypothalamic orexin system regulates both diet preference and anticipation of food rewards making it a likely target to modulate reward-based feeding behavior. In the current manuscript we hypothesized that orexin signaling mediates food-motivated behaviors and reward-based feeding behavior. We further hypothesized that orexin neurons and targets of the orexin system become activated in response to cues associated with the consumption of palatable food. Data from these studies suggest that orexin signaling promotes progressive ratio responding for palatable foods while blockade of orexin signaling attenuates reward-based feeding of a high fat diet. In addition, cues linked to the consumption of chocolate, or the receipt of a daily meal, activate the orexin system and its target regions differentially. Collectively, these data suggest that orexin signaling mediates reward-based feeding behavior and, within specific target regions, may regulate cue-induced overconsumption of palatable foods.
超越稳态需求的消费，在这里被称为基于奖励的进食行为，是导致全球当前肥胖流行的一个主要因素。重要的是，基于奖励的进食可以由食物的美味、口感和质地，以及与美味食物消费相关的线索所驱动。下丘脑食欲素系统调节饮食偏好和对食物奖励的预期，使其成为调节基于奖励的进食行为的可能靶点。在当前的手稿中，我们假设食欲素信号介导食物动机行为和基于奖励的进食行为。我们进一步假设，食欲素神经元和食欲素系统的靶点会对与食用美味食物相关的线索做出反应而被激活。这些研究的数据表明，食欲素信号促进了美味食物的递增比率反应，而食欲素信号的阻断则减弱了高脂肪饮食的基于奖励的进食。此外，与巧克力消费或每日膳食摄入相关的线索会以不同的方式激活食欲素系统及其靶区。总的来说，这些数据表明，食欲素信号介导了基于奖励的进食行为，并且在特定的靶区中，可能调节与线索相关的对美味食物的过度消费。
