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体外持续低剂量率 125I 种子对前列腺癌细胞的相对生物效应和细胞杀伤效力。

Relative biological effectiveness and cell-killing efficacy of continuous low-dose-rate 125I seeds on prostate carcinoma cells in vitro.

机构信息

Peking University 3rd Hospital. Beijing, China.

出版信息

Integr Cancer Ther. 2010 Mar;9(1):59-65. doi: 10.1177/1534735409357758. Epub 2010 Feb 11.

DOI:10.1177/1534735409357758
PMID:20150222
Abstract

The aim of this study was to determine the effects of (125)I seeds on prostate carcinoma (PC3) cells. The relative biological effectiveness of (125)I seeds on PC3 cells with respect to (60)Co gamma rays was 1.4. Both 4 Gy of (60)Co gamma ray and (125)I seed irradiation increased the percentage of cells in G(2) phase, but there was no significant difference between these 2 types of radiation. Significantly, (125)I seeds induced higher apoptotic rates of PC3 cells compared with (60)Co gamma ray irradiation. Furthermore, Bcl-2 expression, but not caspase-3 activity, in PC3 cells was downregulated after irradiation with (125)I seed or (60)Co gamma rays.

摘要

本研究旨在确定 125I 种子对前列腺癌（PC3）细胞的影响。125I 种子对 PC3 细胞的相对生物效应相对于 60Co γ射线为 1.4。4 Gy 的 60Co γ射线和 125I 种子照射均增加了 G2 期细胞的百分比，但这两种辐射之间没有显著差异。值得注意的是，与 60Co γ射线照射相比，125I 种子诱导 PC3 细胞的凋亡率更高。此外，PC3 细胞中 Bcl-2 的表达在接受 125I 种子或 60Co γ射线照射后下调，但 caspase-3 的活性没有变化。

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