9 号染色体和 10 号染色体的缺失预示着低级别胶质瘤预后不良。
Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas.
机构信息
Service de Neurologie 2 - Mazarin, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France.
出版信息
Neuro Oncol. 2010 Jan;12(1):2-6. doi: 10.1093/neuonc/nop002. Epub 2009 Oct 15.
Abstract
The loss of chromosomes 1p-19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p-19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. LOH on 9p and 10q were associated with shortened PFS (P = .01 and .03, respectively) on univariate analysis. On multivariate analysis, LOH on 9p remained significant for PFS (P = .05), whereas LOH on 10q had a significant effect on OS (P = .02). Search for LOH 9p and 10q appears to be a useful complement to analysis of chromosomes 1p-19q in LGGs.
摘要
目前，1p-19q 染色体缺失是低级别胶质瘤（LGG）中唯一确定的预后分子改变。在一系列 231 例 LGG 中，我们对染色体 1p、9p、10q 和 19q 的杂合性丢失（LOH）进行了研究。在单因素和多因素分析中，染色体 1p-19q 的缺失与无进展生存期（PFS）和总生存期（OS）的延长呈强相关。9p 和 10q 的 LOH 在单因素分析中与 PFS 缩短相关（P =.01 和 P =.03）。在多因素分析中，9p 的 LOH 对 PFS 仍有显著影响（P =.05），而 10q 的 LOH 对 OS 有显著影响（P =.02）。在 LGG 中，寻找 9p 和 10q 的 LOH 似乎是分析染色体 1p-19q 的有益补充。
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