Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA.
Am J Pathol. 2010 Mar;176(3):1065-71. doi: 10.2353/ajpath.2010.090850. Epub 2010 Feb 11.
Cell survival depends on a complex interplay of processes including homeostatic pathways and cytoprotective mechanisms. Autophagy is a physiological process involved in the basal turnover of long-lived proteins and organelles and also comprises an integral part of the cellular stress response. The significance of autophagy in regulating neural cell fate has become increasingly recognized and agents targeting autophagy are of increasing therapeutic interest. This review summarizes the recent expansion of our understanding of the scope of this physiological process.
细胞存活依赖于包括动态平衡途径和细胞保护机制在内的复杂相互作用过程。自噬是一个参与长寿命蛋白和细胞器基础更新的生理过程，也是细胞应激反应的一个组成部分。自噬在调节神经细胞命运中的作用已得到越来越多的认识，靶向自噬的药物也越来越受到治疗的关注。本文综述了我们对这一生理过程范围的理解的最新扩展。
