Department of Microbiology, Harbin Medical University, Harbin 150081, China.
Viruses. 2020 Apr 4;12(4):399. doi: 10.3390/v12040399.
RNA granules, aggresomes, and autophagy are key players in the immune response to viral infections. They provide countermeasures that regulate translation and proteostasis in order to rewire cell signaling, prevent viral interference, and maintain cellular homeostasis. The formation of cellular aggregates and inclusions is one of the strategies to minimize viral infections and virus-induced cell damage and to promote cellular survival. However, viruses have developed several strategies to interfere with these cellular processes in order to achieve productive replication within the host cells. A review on how these mechanisms could function as modulators of cell signaling and antiviral factors will be instrumental in refining the current scientific knowledge and proposing means whereby cellular granules and aggregates could be induced or prevented to enhance the antiviral immune response in mammalian cells.
RNA 颗粒、聚集物和自噬是病毒感染免疫反应的关键因素。它们提供了调节翻译和蛋白质稳态的对策，以重新布线细胞信号，防止病毒干扰，并维持细胞内稳态。细胞聚集体和包含物的形成是减少病毒感染和病毒诱导的细胞损伤并促进细胞存活的策略之一。然而，病毒已经开发了几种策略来干扰这些细胞过程，以在宿主细胞内实现有效的复制。关于这些机制如何作为细胞信号转导和抗病毒因子调节剂发挥作用的综述，对于完善当前的科学知识并提出诱导或预防细胞颗粒和聚集物的方法以增强哺乳动物细胞的抗病毒免疫反应将是非常有帮助的。
