Department of Reproductive Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0633, USA.
J Clin Endocrinol Metab. 2010 Apr;95(4):1786-92. doi: 10.1210/jc.2009-2106. Epub 2010 Feb 11.
Serum anti-Müllerian hormone (AMH) levels are significantly elevated in adolescents with polycystic ovary syndrome (PCOS) compared to normal controls. Whether adolescents with oligomenorrhea have elevated AMH levels is unknown.
This study was performed to assess serum AMH levels in oligomenorrheic (OLIGO) girls without evidence of hyperandrogenism.
This was a prospective study comparing AMH levels in OLIGO, PCOS, and normal control adolescents.
The study was conducted through four tertiary academic medical centers.
The study groups were comprised of OLIGO (n = 24), PCOS (n = 153), and normal adolescent girls (n = 39), as well as PCOS (n = 73) and normal adult women (n = 36).
In each subject, serum AMH levels were assessed in the early to midfollicular phases for regularly menstruating subjects and on an arbitrary day for OLIGO or PCOS subjects.
MAIN OUTCOME MEASURE(S): Basal serum AMH levels were assessed among OLIGO, PCOS, and normal girls, in addition to PCOS and normal women.
OLIGO girls had serum AMH levels (5.33 +/- 0.47 ng/ml) that were significantly greater than the normal adolescents (3.05 +/- 0.31 ng/ml) and adults (2.33 +/- 0.22 ng/ml), but similar to values seen in the PCOS adolescents (5.28 +/- 0.26 ng/ml) and adults (6.36 +/- 0.47 ng/ml). Obese adolescents and PCOS women had significantly lower AMH levels compared to lean controls (P < 0.02).
In OLIGO adolescents, elevated serum AMH levels suggest increased antral follicle number similar to that observed in girls with PCOS.
与正常对照组相比，患有多囊卵巢综合征（PCOS）的青少年血清抗苗勒管激素（AMH）水平显著升高。月经稀发的青少年是否有升高的 AMH 水平尚不清楚。
本研究旨在评估无高雄激素血症证据的月经稀发（OLIGO）女孩的血清 AMH 水平。
这是一项比较 OLIGO、PCOS 和正常对照组青少年 AMH 水平的前瞻性研究。
该研究在四个三级学术医疗中心进行。
研究组包括 OLIGO（n = 24）、PCOS（n = 153）和正常青春期女孩（n = 39），以及 PCOS（n = 73）和正常成年女性（n = 36）。
在每个受试者中，在月经规律的受试者的早卵泡期至中期和 OLIGO 或 PCOS 受试者的任意一天评估血清 AMH 水平。
评估 OLIGO、PCOS 和正常女孩的基础血清 AMH 水平，以及 PCOS 和正常女性的 AMH 水平。
OLIGO 女孩的血清 AMH 水平（5.33 +/- 0.47 ng/ml）明显高于正常青少年（3.05 +/- 0.31 ng/ml）和成年女性（2.33 +/- 0.22 ng/ml），但与 PCOS 青少年（5.28 +/- 0.26 ng/ml）和成年女性（6.36 +/- 0.47 ng/ml）相似。肥胖的青少年和 PCOS 女性的 AMH 水平明显低于瘦对照组（P < 0.02）。
在 OLIGO 青少年中，升高的血清 AMH 水平提示窦卵泡数增加，类似于 PCOS 女孩。
