Department of Surgery, Tokyo Women's Medical University Medical Center East, 2-1-10 Nishiogu Arakawa-ku, Tokyo 116-8567, Japan.
Anticancer Res. 2010 Jan;30(1):221-6.
It is difficult to perform radical surgery for esophageal cancer with multiple lymph node metastases. Therefore, effective neoadjuvant adjuvant treatment is necessary to achieve successful radical resection. The use of neoadjuvant chemotherapy of docetaxel, cisplatin (CDOP) and 5-fluorouracil (5-FU) (DCF) in an advanced case is reported. The patient (a 67-year-old female) was diagnosed with esophageal cancer, T3, N4, M0, stage IVa with a large number of lymph node metastases in the mediastinum and in the abdominal cavity. Neoadjuvant DCF chemotherapy was initiated in August 2006. Adverse events were mild. A complete response of the lymph node metastases in the abdominal cavity and a partial response of the esophageal lesion were achieved. The surgical procedure included a right thoracolaparotomy followed by a subtotal excision of the esophagus and two-field lymph node dissection. The cancer was diagnosed to be moderately differentiated squamous cell cancer, pT2, pN4(3c) and pstage IVa. The histological efficacy of the chemotherapy was determined to be grade 1a. Two additional courses of DCF therapy were administered followed by postoperative adjuvant chemotherapy.
对于伴有多处淋巴结转移的食管癌，进行根治性手术非常困难。因此，需要进行有效的新辅助辅助治疗，以实现根治性切除。本文报道了一例晚期病例中使用多西紫杉醇、顺铂（CDOP）和 5-氟尿嘧啶（5-FU）（DCF）新辅助化疗的情况。患者（一名 67 岁女性）被诊断为食管癌，T3、N4、M0，IVa 期，纵隔和腹腔内有大量淋巴结转移。2006 年 8 月开始进行新辅助 DCF 化疗。不良反应轻微。腹部淋巴结转移完全缓解，食管病变部分缓解。手术包括右胸腹联合入路，行食管次全切除和两野淋巴结清扫。癌症被诊断为中度分化鳞癌，pT2、pN4(3c)和 pIVa 期。化疗的组织学疗效为 1a 级。另外进行了两个疗程的 DCF 治疗，随后进行了术后辅助化疗。
