Noro Hiroshi, Hirao Takafumi, Takaichi Shohei, Son Chihyon, Iwamoto Kazuya, Kono Emiko, Yasumasa Keigo, Mizuno Hitoshi, Morimoto Yoshikazu, Hatanaka Nobutaka, Yamasaki Yoshio
Dept. of Surgery, Japan Community Health care Organization(JCHO) Osaka Hospital.
Gan To Kagaku Ryoho. 2016 Nov;43(12):2178-2180.
The patient was a 66-year-old woman, who was diagnosed with cT3N3M0, cStage III esophageal cancer with widespread lymph node metastases in the mediastinum and abdomen. She was treated with 2 courses of chemotherapy with docetaxel/ cisplatin/5-FU(DCF therapy). CT and FDG PET-CT showed a significant reduction in both the primary tumor and the metastatic lymph nodes following treatment. We performed subtotal esophagectomy and gastric tube reconstruction with lymphadenectomy. The histopathological findings showed no residual viable tumor cells or foreign body-type giant cells with necrosis. The pathological effect of chemotherapy was defined as Grade 3(pCR). Our case suggested that DCF chemotherapy is potentially a very effective treatment for advanced esophageal cancer with widespread lymph node metastases.
该患者为一名66岁女性，被诊断为cT3N3M0，c期III型食管癌，纵隔和腹部有广泛淋巴结转移。她接受了2个疗程的多西他赛/顺铂/5-氟尿嘧啶化疗（DCF疗法）。治疗后CT和FDG PET-CT显示原发肿瘤和转移淋巴结均显著缩小。我们进行了次全食管切除术、胃管重建及淋巴结清扫术。组织病理学检查结果显示无残留存活肿瘤细胞或伴有坏死的异物型巨细胞。化疗的病理效果定义为3级（pCR）。我们的病例表明，DCF化疗可能是治疗伴有广泛淋巴结转移的晚期食管癌的一种非常有效的方法。
