Department of Radiotherapy, University Hospital Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany.
Anticancer Res. 2010 Jan;30(1):227-31.
To comprehensively summarize the most important literature regarding the late effects of radiotherapy to the abdomen in childhood and adolescence.
Published trials, studies and series were identified using the PubMed database. The key words late effects, late sequelae, child, radiation, radiotherapy, abdomen, kidney, liver, and bowel were used.
A dose-volume effect is confirmed for liver irradiation. Radiation with doses <20 Gy to major parts of the liver or higher doses to smaller parts seems to be safe. Kidney function impairment due to radiation is rare in children. Renal sequelae may occur after radiation to the remaining kidney in patients who underwent nephrectomy or who received higher doses to both kidneys. Several reports describe small bowel obstruction as a sequelae of surgery, but radiotherapy seems to be less important.
Several retrospective reports describe radiation-associated late sequelae in children. However, there is still a lack of sufficient data regarding the characterization of dose-volume effects.
全面总结儿童和青少年腹部放疗后晚期效应的重要文献。
使用 PubMed 数据库确定已发表的试验、研究和系列研究。使用的关键词为晚期效应、晚期后遗症、儿童、辐射、放疗、腹部、肾、肝和肠。
肝脏照射的剂量-体积效应得到证实。肝脏主要部位照射<20Gy 或较小部位照射较高剂量似乎是安全的。儿童因辐射导致肾功能损害罕见。肾切除术后或双侧肾脏接受较高剂量照射的患者，可能会发生肾后遗留肾的放射性后遗症。有几篇报道描述了小肠梗阻作为手术的后遗症，但放疗似乎不太重要。
一些回顾性报告描述了儿童放疗相关的晚期后遗症。然而，关于剂量-体积效应的特征，仍然缺乏足够的数据。
