Rihmer Zoltán
Semmelweis Egyetem, Kútvölgyi Klinikai Tömb, Klinikai és Kutatási Mentálhigiénés Osztály, Budapest, Hungary.
Neuropsychopharmacol Hung. 2009 Dec;11(4):211-5.
Although the possibilities of antidepressive pharmacotherapy are continuously improving, the rate of nonresponders or partial responders is still relatively high. Suicidal behaviour, the most tragic consequence of untreated or unsuccessfully treated depression, commonly develops in the first few weeks of antidepressive treatment before the onset of therapeutic action and is strongly related to certain specific symptoms of depression like anxiety, agitation and insomnia. The present paper reviews the newly discovered and well-documented antidepressive effect of quetiapine in bipolar and unipolar depression with special regards to its early onset of action, and its sleep-improving effects. Both beneficial effects play an important role in the reduction of suicidal risk frequently seen in depressed patients.
尽管抗抑郁药物治疗的可能性在不断提高，但无反应者或部分反应者的比例仍然相对较高。自杀行为是未治疗或治疗未成功的抑郁症最悲惨的后果，通常在抗抑郁治疗的最初几周内出现，在治疗作用起效之前，并且与抑郁症的某些特定症状如焦虑、激动和失眠密切相关。本文综述了喹硫平在双相和单相抑郁症中最新发现且有充分文献记载的抗抑郁作用，特别关注其起效早的特点以及改善睡眠的作用。这两种有益作用在降低抑郁症患者常见的自杀风险方面都起着重要作用。
