Department of Neurosciences, Mental Health and Sensory Functions, Suicide Prevention Center Sant'Andrea Hospital, Sapienza University of Rome, Italy.
Riv Psichiatr. 2012 Nov-Dec;47(6):489-97. doi: 10.1708/1178.13055.
Although the possibilities of antidepressive pharmacotherapy are continuously improving, the rate of nonresponders or partial responders is still relatively high. Suicidal behavior, the most tragic consequence of untreated or unsuccessfully treated depression, commonly observed in the first few weeks of antidepressive treatment before the onset of therapeutic action, is strongly related to certain symptoms of depression like insomnia. The present paper reviews the newly discovered and well-documented antidepressive effect of quetiapine in bipolar and unipolar depression with special focus on its early onset of action and its sleep-improving effects. Both beneficial effects play an important role in the reduction of suicidal risk frequently observed in depressed patients.
虽然抗抑郁药治疗的可能性在不断提高，但无反应者或部分反应者的比例仍然相对较高。自杀行为是未经治疗或治疗失败的抑郁症最悲惨的后果，在抗抑郁治疗开始发挥治疗作用之前的最初几周内经常观察到，与失眠等某些抑郁症状密切相关。本文综述了喹硫平在双相和单相抑郁中的新发现和良好记录的抗抑郁作用，特别关注其早期作用和改善睡眠的作用。这两种有益的作用在经常观察到的抑郁患者自杀风险的降低中起着重要作用。
