Department of Neurology III, Aristotle University of Thessaloniki, Thessaloniki, Greece. kimiskid @ med.auth.gr
Eur Neurol. 2010;63(4):205-10. doi: 10.1159/000282735. Epub 2010 Feb 11.
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique which, over the last 25 years, has greatly expanded from a simple method for stimulating the motor cortex to an invaluable tool with multiple research, diagnostic and even therapeutic applications. In this review, we discuss the use of repetitive TMS as a means of suppressing cortical hyperexcitability in drug-resistant epilepsies. The theoretical background and the experimental evidence in favor of this novel therapeutic approach are presented, and a number of open-label and controlled studies in patients with various forms of focal epilepsy are reviewed. It is concluded that, although the therapeutic effects of repetitive TMS in epilepsy appear rather limited, further clinical testing of this rapidly evolving technology is warranted.
经颅磁刺激（TMS）是一种非侵入性的脑刺激技术，在过去的 25 年中，它已经从一种简单的刺激运动皮层的方法发展成为一种具有多种研究、诊断甚至治疗应用的宝贵工具。在这篇综述中，我们讨论了重复 TMS 作为抑制耐药性癫痫中海马过度兴奋的一种手段。本文介绍了这种新的治疗方法的理论背景和实验证据，并回顾了各种局灶性癫痫患者的一些开放性和对照研究。结论是，尽管重复 TMS 在癫痫中的治疗效果似乎相当有限，但仍需要对这项快速发展的技术进行进一步的临床测试。
