过去十年中荷兰中部地区早产儿视网膜病变的发生率。

Incidence of retinopathy of prematurity over the last decade in the Central Netherlands.

机构信息

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands.

出版信息

Neonatology. 2010;98(2):137-42. doi: 10.1159/000280386. Epub 2010 Feb 12.

DOI:10.1159/000280386

PMID:20150751

Abstract

BACKGROUND AND OBJECTIVES

To retrospectively analyze changes in incidence and risk factors of retinopathy of prematurity (ROP) over two periods, 10 years apart, in the central Netherlands.

METHODS

Data of 570 infants admitted between 2001 and 2005, screened for ROP according to the Dutch National guideline, were compared to those of 538 infants admitted between 1991 and 1995.

RESULTS

Incidence of ROP decreased significantly over the last decade (40.9% in 1991-1995 vs. 23.3% in 2001-2005, p < 0.001), together with incidence of severe ROP (stage >or=3) (3.3 vs. 1.2%, p < 0.05). In infants with a birth weight (BW) <1,000 g incidence of ROP dropped significantly (67.0 vs. 41.8%, p < 0.001), as well as incidence of severe ROP (8.1 vs. 3.0%, p < 0.05). For infants with a BW >or=1,000 g incidence of ROP also declined significantly (27.1 vs. 13.0%, p < 0.001), that of severe ROP remained unchanged (0.8 vs. 0.3%). In both periods gestational age, duration of artificial ventilation, small for gestational age (SGA) and postnatal steroids were independent risk factors for ROP.

CONCLUSIONS

In the central Netherlands, incidence of ROP and severe ROP has significantly decreased, also in infants with BW <1,000 g. Risk factors remained unchanged.

摘要

背景与目的

回顾性分析荷兰中部两个 10 年间隔时期早产儿视网膜病变（ROP）的发病情况及相关危险因素。

方法

比较了 2001 年至 2005 年间收治的 570 例根据荷兰国家指南筛查 ROP 的婴儿数据，与 1991 年至 1995 年间收治的 538 例婴儿数据。

结果

过去十年ROP 的发病率显著下降（1991-1995 年为 40.9%，2001-2005 年为 23.3%，p<0.001），重度 ROP（分期>或=3）的发病率也显著下降（3.3%比 1.2%，p<0.05）。在出生体重（BW）<1000g 的婴儿中，ROP 的发病率显著下降（67.0%比 41.8%，p<0.001），重度 ROP 的发病率也显著下降（8.1%比 3.0%，p<0.05）。对于 BW≥1000g 的婴儿，ROP 的发病率也显著下降（27.1%比 13.0%，p<0.001），但重度 ROP 的发病率保持不变（0.8%比 0.3%）。在两个时期，胎龄、人工通气时间、小于胎龄儿（SGA）和出生后类固醇都是 ROP 的独立危险因素。