Isaza Gloria, Arora Sourabh, Bal Manpartap, Chaudhary Varun
Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
J Pediatr Ophthalmol Strabismus. 2013 Jan-Feb;50(1):27-32. doi: 10.3928/01913913-20121127-02. Epub 2012 Dec 4.
To study the incidence of retinopathy of prematurity (ROP) in a neonatal intensive care unit and obtain information on risk factors associated with ROP.
Four hundred twenty-three infants were screened for ROP between July 2006 and July 2010. Demographic information, clinical data, and risk factors were reviewed.
The incidence was 40.4% (171 infants) for ROP, 9.2% (39 infants) for severe ROP, and 5.67% (24 infants) for laser treatment. Mean gestational age and birth weight were significantly lower among infants with ROP versus those without ROP (26 ± 0.13 vs 28.55 ± 0.12 weeks, P < .0001 and 840.5 ±17.49 vs 1,190.24 ± 20.20 g, P < .0001, respectively). Birth weight (P < .001), gestational age (P < .001), mechanical ventilation therapy (P = .039), and necrotizing enterocolitis (P = .019) were independent risk factors for ROP.
Gestational age and birth weight were the most significant risk factors for developing ROP. The study population had an elevated percentage of infants with birth weight less than 1,000 g (extremely low birth weight), yet there was no corresponding increase in severe ROP incidence and treatment when compared to other studies.
研究新生儿重症监护病房中早产儿视网膜病变（ROP）的发病率，并获取与ROP相关的危险因素信息。
2006年7月至2010年7月期间，对423名婴儿进行了ROP筛查。回顾了人口统计学信息、临床数据和危险因素。
ROP的发病率为40.4%（171名婴儿），重度ROP的发病率为9.2%（39名婴儿），激光治疗的发病率为5.67%（24名婴儿）。与未患ROP的婴儿相比，患ROP的婴儿平均胎龄和出生体重显著更低（分别为26±0.13周对28.55±0.12周，P<.0001；840.5±17.49克对1190.24±20.20克，P<.0001）。出生体重（P<.001）、胎龄（P<.001）、机械通气治疗（P=.039）和坏死性小肠结肠炎（P=.019）是ROP的独立危险因素。
胎龄和出生体重是发生ROP的最显著危险因素。研究人群中出生体重低于1000克（极低出生体重）的婴儿比例有所升高，但与其他研究相比，重度ROP的发病率和治疗率并未相应增加。
