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Targeting the checkpoint kinase WEE1: selective sensitization of cancer cells to DNA-damaging drugs.

作者信息

Indovina Paola, Giordano Antonio

机构信息

Department of Human Pathology and Oncology, University of Siena, Siena, Italy.

出版信息

Cancer Biol Ther. 2010 Apr 1;9(7):523-5. doi: 10.4161/cbt.9.7.11276.

DOI:10.4161/cbt.9.7.11276
PMID:20150761
Abstract
摘要

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Targeting the checkpoint kinase WEE1: selective sensitization of cancer cells to DNA-damaging drugs.靶向检查点激酶WEE1：癌细胞对DNA损伤药物的选择性增敏作用
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2
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Wee1 kinase as a target for cancer therapy.Wee1 激酶作为癌症治疗的靶点。
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Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents.小分子抑制剂 MK-1775 抑制 Wee1 激酶可选择性增强 p53 缺陷型肿瘤细胞对 DNA 损伤药物的敏感性。
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Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation.chk1 抑制和 wee1 抑制协同作用以阻碍细胞增殖。
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里西洛他汀增强了 TP53 突变型头颈部鳞状细胞癌细胞中adavosertib 诱导的有丝分裂灾难。
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Wee1 Inhibitor AZD1775 Effectively Inhibits the Malignant Phenotypes of Esophageal Squamous Cell Carcinoma and .Wee1抑制剂AZD1775有效抑制食管鳞状细胞癌的恶性表型 以及 。 （注：原文结尾“and.”表述不完整，翻译时尽量忠实原文进行了呈现。）
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A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia.小分子 WEE1 抑制剂 AZD1775 通过损伤同源重组并增强 DNA 损伤和细胞凋亡协同奥拉帕利增强急性白血病疗效。
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Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.葫芦素B诱导的ATM介导的DNA损伤以ROS依赖的方式导致G2/M期细胞周期停滞。
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