通过二维凝胶电泳鉴定的小鼠性腺组织中蛋白质的发育外观。

Developmental appearance of proteins identified by two-dimensional gel electrophoresis in mouse gonadal tissue.

作者信息

Durbin E J, Erickson R P, Van Keuren M L, Iacob R A, Kurnit D M

机构信息

Department of Human Genetics, University of Michigan School of Medicine, Ann Arbor.

出版信息

Mol Reprod Dev. 1991 Mar;28(3):245-8. doi: 10.1002/mrd.1080280305.

DOI:10.1002/mrd.1080280305

PMID:2015082

Abstract

Gonadal protein patterns of the mouse were studied during fetal development by two-dimensional gel electrophoresis. Fetal mice at days 8.5, 10.5, 12.5, and 14.5 post-coitum were analyzed for male or female specific proteins. Although no sex specific proteins were found, several proteins were found which were expressed in significantly different amounts in the two sexes at about the time of gonadal differentiation. Hence, quantitative differences, rather than qualitative ones, could be related to the initiation of testis or ovary development.

摘要

通过二维凝胶电泳研究了小鼠在胎儿发育期间的性腺蛋白质模式。分析了交配后8.5天、10.5天、12.5天和14.5天的胎儿小鼠的雄性或雌性特异性蛋白质。虽然未发现性别特异性蛋白质，但发现了几种蛋白质，它们在性腺分化时在两性中的表达量存在显著差异。因此，数量上的差异而非质量上的差异可能与睾丸或卵巢发育的起始有关。