罗库溴铵在 2 型糖尿病患者全身麻醉中的药效学作用。
The pharmacodynamic effects of rocuronium during general anesthesia in patients with type 2 diabetes mellitus.
机构信息
Department of Anesthesiology and Reanimation, Ege University School of Medicine, Izmir, Turkey.
出版信息
Minerva Anestesiol. 2010 Feb;76(2):115-9. Epub 2009 Dec 23.
AIM
The aim of this prospective study was to investigate whether the neuromuscular response to rocuronium is affected by the presence of type 2 diabetes mellitus.
METHODS
Neuromuscular functions were measured after the administration of 0.6 mg/kg rocuronium with train-of-four stimulations in patients with type 2 diabetes mellitus (DM, N=14) and without diabetes mellitus (control, N=14) during isoflurane based general anesthesia. The onset time, clinical duration and recovery index of rocuronium were compared in the two groups.
RESULTS
The mean onset time (136 +/- 40 vs 118 +/- 20 s), clinical duration (51 +/- 11 vs 48 +/- 11 min) and recovery index (6.0 +/- 2.5 vs 5.9 +/- 1.4 min) of the neuromuscular block were not significantly different between the DM and control groups, respectively (p>0.05).
CONCLUSIONS
The present study has proven that the rocuronium-induced neuromuscular block was not affected in patients with type 2 diabetes mellitus during isoflurane based general anesthesia.
目的
本前瞻性研究旨在探讨 2 型糖尿病患者中罗库溴铵的神经肌肉反应是否受其影响。
方法
在异氟醚全身麻醉下，用四脉冲刺激给予 0.6mg/kg 罗库溴铵后，测量 2 型糖尿病（DM，N=14）和无糖尿病（对照组，N=14）患者的神经肌肉功能。比较两组罗库溴铵的起效时间、临床持续时间和恢复指数。
结果
DM 组和对照组的平均起效时间（136 +/- 40 对 118 +/- 20 s）、临床持续时间（51 +/- 11 对 48 +/- 11 min）和恢复指数（6.0 +/- 2.5 对 5.9 +/- 1.4 min）差异均无统计学意义（p>0.05）。
结论
本研究证明，在异氟醚全身麻醉下，2 型糖尿病患者的罗库溴铵诱导的神经肌肉阻滞不受影响。
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