Pestel G, Closhen D, Zimmermann A, Werner C, Weber M M
Klinik für Anästhesiologie, Universitätsmedizin der Johannes-Gutenberg Universität, Langenbeckstr. 1, 55131 Mainz, Germany.
Anaesthesist. 2013 Jan;62(1):9-19. doi: 10.1007/s00101-012-2089-y.
Diabetes is a common disease in Germany. Due to diabetes-associated end-organ disease, such as large and small vessel disease and neuropathy, diabetic patients require more intense anesthesia care during the perioperative phase. An in-depth and comprehensive medical history focusing on hemodynamic alterations, gastroparesis, neuropathy and stiff joint syndrome is a cornerstone of perioperative care and may affect outcome of diabetes patients more than specific anesthetic medications or the anesthetic procedure. Intraoperative anesthetic care needs to focus on preservation of hemodynamic stability, perioperative infection control and maintenance of glucose homeostasis. Whereas some years ago strict glucose control by aggressive insulin therapy was adamantly advocated, the results of recent studies have put the risk of such therapeutic algorithms into perspective. Therefore, optimized perioperative care of diabetic patients consists of setting a predefined targeted blood glucose level, evidence-based therapeutic approaches to reach that goal and finally adequate and continuous monitoring and amendment of the therapeutic approach if required.
糖尿病在德国是一种常见疾病。由于糖尿病相关的终末器官疾病,如大血管和小血管疾病以及神经病变,糖尿病患者在围手术期需要更强化的麻醉护理。一份深入且全面的病史,重点关注血流动力学改变、胃轻瘫、神经病变和关节僵硬综合征,是围手术期护理的基石,对糖尿病患者预后的影响可能超过特定的麻醉药物或麻醉操作。术中麻醉护理需要注重维持血流动力学稳定、围手术期感染控制以及维持血糖稳态。尽管几年前坚决主张通过积极的胰岛素治疗进行严格的血糖控制,但近期研究结果已让人们正确看待此类治疗方案的风险。因此,糖尿病患者围手术期的优化护理包括设定一个预先确定的目标血糖水平、基于证据的实现该目标的治疗方法,以及最后在必要时进行充分且持续的监测和调整治疗方法。