ANKK1（DRD2）基因的TaqI A多态性与6至13岁捷克男孩注意力缺陷多动障碍之间的关联。
The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years.
作者信息
Paclt Ivo, Drtilkova Ivana, Kopeckova Marta, Theiner Pavel, Serý Omar, Cermakova Nikol
机构信息
Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague and General Teaching Hospital, Czech Republic.
出版信息
Neuro Endocrinol Lett. 2010;31(1):131-6.
OBJECTIVE
The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity.
PATIENTS AND METHODS
Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989).
RESULTS
The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719).
CONCLUSIONS
Our results presented a highly positive correlation between the combined type of ADHD without co-morbidity and ANKK l (DRD2) polymorphism .
目的
本研究旨在探讨儿童注意缺陷多动障碍（ADHD）合并类型与多巴胺D2受体（DRD2）基因Taq IA多态性之间的相关性。我们假设在无共病的ADHD合并类型患者中，DRD2多态性呈正相关。
患者与方法
我们的研究样本包括586名年龄在6至13岁之间、来自捷克的无血缘关系男孩。ADHD组由269名男孩组成，对照组由317名男孩组成。采用Grandy（Grandy等人，1989年）描述的引物对DRD2多态性进行PCR检测。
结果
基因型频率比较显示，研究组之间存在统计学上的高度显著差异（p<0.0001）。两组等位基因频率比较也发现了统计学上的显著差异（p<0.0001），A1等位基因患ADHD的风险高4.359倍（风险比=4.359，RR的95%置信区间=3.5753至5.3144，优势比=七.7824；OR的95%置信区间=10.315至13.6719）。
结论
我们的结果表明，无共病的ADHD合并类型与ANKK1（DRD2）多态性之间存在高度正相关。
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